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In SLE, hydroxychloroquine suppresses trained immunity by inhibiting H3K27ac and H3K4me3 modifications at inflammation-related genes (169)

SIRT1 is also known as the "longevity gene" because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer

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Previous study established a LPS-induced murine sepsis model (65) and found that small, biocompatible, MRI-visible melanin nanoparticles (MMPP) significantly improved cardiac function and attenuated myocardial structural disorders