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In individuals without an increased oxidative burden, circulating GSH remained stable

Intracerebroventricular administration of L-arginine improves spatial memory acquisition in triple transgenic mice via reduction of oxidative stress and apoptosis

Int J Mol Sci (2022) 23(13):6879

The increase of ROS within a high oxidative stress level (by decreasing of the antioxidant GPx enzyme) increases the possibility of lipid oxidation, especially LDL-cholesterol and thus favors the formation of anti-LDL-oxidized cholesterol antibodies, which will lead to the initiation of an immune and vascular aggression process (13-18)