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For example, several studies using proton magnetic resonance spectroscopy have reported reduced levels of N -acetyl aspartate, a marker of impaired mitochondrial energy production, in the brains of bipolar disorder patients compared with healthy controls [121,122,123,124,125]

Indeed, balance of synaptic changes in neuron models can be achieved by careful adjustment of plasticity windows in depression-biased STDP rules (Song et al., 2000