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177 Transcranial electrical stimulation (tES) is the most widely used method and involves the application of a small direct or alternating current to the scalp via two electrodes

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Its mechanisms include modulation of neurotransmitter signaling that promotes slow-wave activity, reduction of nighttime cortisol and stress hormone interference with sleep architecture, and support for the timing and depth of the sleep cycle itself

While more expensive than monotherapy, the 50% additional weight loss over semaglutide alone (15-25% vs 10-15%) justifies the investment for those seeking maximum medical weight loss without surgery