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Preclinical studies have shown that PD-1/PD-L1 blockade can mobilize monocyte-derived macrophages, enabling their infiltration into the brain to reduce pathology and combat cognitive decline in 5XFAD AD mice [350, 351]

In another study using rabbit Achilles tenocytes, the administration of IGF-1 led to the increased expression of type I collagen gene at 0.1 and 1 ng/mL, followed by a decrease at 10 ng/mL (Rieber et al., 2023)

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