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More recently, the A946T variant alone was confirmed to lead to increased basal type I IFN activity in reporter cell lines due to increased MDA5 ATPase activity, which may enhance filament formation on dsRNA and downstream signaling (115)

It is not intended for human or veterinary use, and must not be used for diagnostic, therapeutic, or clinical purposes

Intriguingly, not only coagulation factors which are currently known to need vitamin-k-depended -carboxylation, but also Gla proteins have been found to undergo posttranslational -carboxylation [186]

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