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However, in two-hit mouse models, exposure to EIII followed by the administration of autoantibodies leads to target cell damage, including endothelial apoptosis and hemorrhage (Figure 2, lower panel) [119,120,122,147,148]

SumidaKMolnarMZPotukuchiPKHassanFThomasFYamagataKet al

Proposed Mechanisms of Hyperoxia-Induced Acute Kidney Injury Multiple mechanisms of hyperoxia-induced organ damage have been presented in the medical literature

In this view, the imbalance between commensals and pathogens (namely dysbiosis) would enhance the entry of bacterial and food antigens into the systemic circulation, triggering auto-aggressive processes [180]