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Medical Pharmacology Chapter 2: General Principles: Pharmacokinetics Cytochrome P450 Enzyme Induction: Following repeated administration, some drugs increase the amount of P450 enzyme usually by: Increase enzyme synthesis rate (induction) Reduced enzyme degradation rate Cytochrome P450 enzyme inhibition: Certain drugs, by binding to the cytochrome component, act to competitively inhibit metabolism
You may learn more about methylation here and here (its a critical process for many body processes such as detoxification too)
Canagliflozin has been shown to decrease levels of the blood marker for diabetes hemoglobin Hb1c by between 0.77% to 1.16% when given alone or 7.8% to 8.1% when combined with insulin
As systemic inflammation drops, you may see improvements in triglycerides and HDL
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