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Veganism and vegetarianism can contribute to a deficiency in this essential nutrient

In some instances, conventionally used methods of sterilization (e.g., heat treatment (e.g., in an autoclave), gamma irradiation, filtration) lead to irreversible degradation of polymeric components (e.g., thermosetting, gelling or mucoadhesive polymer components) and/or the active agent in the formulation

Most experienced researchers recommend dropping back to a lower escalation dose and working up gradually, even with prior GLP-1 agonist experience