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In the genetic engineering strategy, researchers have induced tumorigenesis by targeting and integrating oncogenic gene expression vectors or using targeted knockdown of tumor suppressor genes mediated by the CRISPR/Cas9 system ( Xenotransplantation serves as the primary methodology for developing zebrafish breast cancer models ( Figure 1 ), involving engraftment of foreign tissues across species barriers

J Cardiol 1991;21(2):493-504

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