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The main POF inducer is the reproductive system ( 2.1.1 Genetic factors Patients with POF have been found to harbor chromosome abnormalities and genetic polymorphisms associated with the development of POF, and among them, 50%90% of patients present the idiopathic type ( 2.1.2 Immune factors The ovary is a common autoimmune target in organ-specific and systemic autoimmune diseases, and these can lead to POF, polycystic ovarian syndrome, unexplained infertility, or endometriosis ( Figure 2 )

It highlighted 1) the safety of the NAC regimen and suggested potential clinical benefits, including 2) a trend towards longer pregnancy duration in drug-treated participants, and 3) a reduction in neonatal morbities linked to oxygen radical disease in the newborn spectrum

Beyond cellular assays, the study also explored the structural properties and histone-binding potential of the Epitalon peptide through computational modeling and molecular docking simulations

However, further studies have shown its benefits to the musculoskeletal system