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The vital substance is significantly involved in the detoxification of xenobiotics (foreign, mostly chemical substances such as pesticides, preservatives), heavy metals and harmful mould toxins

Protein quantification was carried out using the MaxLFQ algorithm as implemented in the DIA-NN R package ( and the number of peptides quantified in each protein group was counted as implemented in the DiannReportGenerator package ( 71

Unaffected individuals from both cohorts obtained from Kahemba were not considered to have konzo at the time of sampling following the 3 main criteria for diagnosis outlined by the World Health Organization

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