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Use of certain medications that may interact with B12 or choline metabolism (e.g., metformin, proton pump inhibitors, or anticholinergic drugs)

[DOI] [PubMed] [Google Scholar] 14.Raina N, Rani R, Thakur VK, Gupta M

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[35] While there is some evidence that estrogen may play a role in the cause of BPH, this effect appears to be mediated mainly through local conversion of androgens to estrogen in the prostate tissue rather than a direct effect of estrogen itself