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To verify the functions of these overlapping genes, we conducted KEGG enrichment analysis and found that these genes were significantly enriched in the VEGF signaling pathway, FoxO signaling pathway, MAPK signaling pathway, mTOR signaling pathway, and Wnt signaling pathway (Figure 1B)

Also, previous reports have shown that acute treatment with MC4R agonists results in increased repetitive behavior and increased anxiety-like behavior in both the presence and absence of psychological stress [43, 44, 45]

(2) developing combination therapies for specific pathological subtypes, including potential synergistic benefits with mitochondria-targeted antioxidants (e.g., MitoQ) or bile acid modulators (e.g., ursodeoxycholic acid, UDCA) in MASH patients with prominent ballooning degeneration or cholestatic features

International Journal of Dermatology