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Clinically, hyperuricemia is defined as serum uric acid concentrations 7 mg/dl (0.42 mmol/l) at physiological temperature and pH (4)

These interactions may further impact complement activation, immune cell recruitment, and the amplification of inflammation (28)

In an animal study using 5-dihydrotestosterone + insulin treatment to simulate a miscarriage model in PCOS patients, NAC supplementation improved fetal survival rates in model mice by protecting mitochondrial function, restoring the balance of SOD1 and the Keap1/Nrf2 antioxidant response, reducing excessive ROS production, and mitigating placental formation defects [57]

Prior to any procedures, animals are anesthetized using a combination of xylazine (10 mg/kg), ketamine (40 mg/kg) and acepromazine (0.75 mg/kg) for up to one hour via the intramuscular route