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In some instances, vapor pressure depression method allows for determination of the osmolarity of a formulation comprising a gelling agent (e.g., a thermoreversible polymer) at a higher temperature wherein the gelling agent is in the form of a gel

Studies in older mice investigating individual cells as well as larger vessels and micro-vessels will be useful in determining which cells of the cerebrovasculature are responsible for these changes and whether there are APOE -driven differences in FAO in both larger and smaller vessels that can affect transport functions