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Yki-Jrvinen H, Luukkonen PK, Hodson L, Moore JB

Consistent with Leydig cells from elderly men, immunofluorescent staining showed FOXO4 predominantly localized in the nucleus of these H 2 O 2 -induced senescent TM3 Leydig cells, but in the cytoplasm of untreated controls (Figure 3B)

Moreover, they reported a 21% spontaneous pregnancy rate in the treatment group compared to 0% in the placebo group.[15] Studies investigating vitamin E in combination with other vitamins have specifically revealed a significant improvement in sperm concentration[16,17] together with a decrease in sperm DNA fragmentation (SDF)[16] and seminal ROS.[17] Keskes-Ammar et al