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Research protocols involving extended IGF1 LR3 use should consider tracking growth hormone and endogenous IGF-1 levels to assess these feedback effects

Gastrointestinal: bloating and abdominal distension, postprandial fullness, belly pain, diarrhea and constipation, belching, nausea/vomiting

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Interestingly, NKX2-1 alterations are also observed in 12% of lung adenocarcinoma (5) and 16% of neuroendocrine prostate cancer patients (6), and NKX2-1 overexpression is associated with increased expression of serine and glycine synthesis enzymes in these cancer types as well