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This comparison illustrates the gap between novel molecular mechanism discovery and validated clinical translation Dihexa represents frontier neuroscience with unresolved questions, while Cerebrolysin represents established but less mechanistically precise neurotrophic therapy

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Mice that are exposed to a PUFA-enriched Western diet and that lack one Gpx4 allele in IECs (Gpx4 +/IEC ), but not wild-type (WT) mice, display signs of epithelial LPO and focal neutrophilic enteritis with granuloma-like accumulation of inflammatory cells