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Based on our GSH-bound OsDHAR structure and other studies from omega class GSTs and bacterial OaGST, the regeneration of OsDHAR may proceed via a disulfide bond link between the G-site GSH and active site cysteine residue

Glossary FMH Food and medicine homology SARS-CoV-2 coronavirus 2 COVID-19 corona virus disease 2019 PACS post-acute COVID-19 syndrome FMH food and medicine homology WHO World Health Organization PHEIC Public Health Emergency of International Concern ACE2 angiotensin-converting enzyme 2 TCM traditional Chinese medicine TMPRSS2 transmembrane serine protease 2 EBV Epstein Barr virus HHV-6 human heroes type 6 BBB blood brain barrier CNS central nervous system MCAS mast cell activation syndrome Ang II angiotensin II ROS reactive oxygen species OD olfactory dysfunction PNS peripheral nervous system OE olfactory epithelium -syn -synuclein PD Parkinsons disease OB olfactory bulb DAD diffuse alveolar damage ECM extracellular matrix PF pulmonary fibrosis ICU intensive care unit IPF idiopathic pulmonary fibrosis EMT epithelial-mesenchymal transition POTS postural orthostatic tachycardia syndrome CCK cholecystokinin GLP-1 glucagon-like peptide-1 SCFAs short-chain fatty acids LPS lipopolysaccharide IBS irritable bowel syndrome AKI acute kidney injury CKD chronic kidney disease PTC proximal tubular cells ED erectile dysfunction ARDS acute respiratory distress syndrome NDDs neurodegenerative diseases Other target abbreviations are listed in the notes of Table 3

Surgery procedure and medication Rats were anesthetized by intraperitoneal injection of thiopental (50 mg/kg) and diazepam (5 mg/kg)

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