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Although some studies have shown that elevated serum UA levels can predict a high risk of ischemic stroke and poor outcomes [140, 141], an increasing body of studies have found that higher levels of UA at admission in stroke patients improved survival and functional outcomes after controlling for the effects of confounding factors [142]

Autoantibodies against the angiotensin receptor AT1, particularly the second loop (AT1-AA) [210], can stimulate NAD(P)H oxidase, leading to increased generation of ROS

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they are trying to solve the situation of an unhealthy brain environment, says Dickenson