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5 Renal targeting challenges and novel approaches The complexity of the kidney, including diverse cell types and structural components, complicates efforts to protect and restore renal function, while challenges in developing effective drug delivery systems for renal diseases are widely acknowledged [73]

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its activation triggers the phospholipase C pathway and the mobilisation of intracellular calcium, which in somatotrophs translates into growth hormone secretion

This signaling is characterized by increased intrinsic and extrinsic signaling involving Bax/BcL-2 proteins, leading to the loss of NK1 receptors after 40 days of PD induction, which results in breathing dysfunction (Falquetto et al., 2020)