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While AOD9604 has not achieved the commercial success initially envisioned, it has contributed valuable insights into the dissociable functions of different regions of the growth hormone molecule and has validated the concept that targeted metabolic effects can be achieved without unwanted growth hormone receptor activation

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The human ortholog was chosen for its high sequence identity (87%, 274/315) and conserved secondary structure (RSMD = 0.220), ensuring functional equivalence to KIN-19 (Supplementary Fig