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Indeed, we observed increased KEAP1 and decreased NRF2 in both macrophages and RANKL-induced osteoclasts, as well as in ankle joints of CIA mouse models, indicating an unbalanced redox environment (Fig

Importantly, the detrimental impact of F.n on the gut community is not limited to UC but also extends to CD, where specific populations like polymorphum are enriched, an effect more pronounced in male hosts ( The pathogenic role of F.n is even more pronounced in CRC, where it functions as a bona fide oncomicrobe

5F, protein banding patterns of MCMs and SP@M were nearly identical according to the Coomassie blue staining assay, demonstrating the effective translocation of MCMs proteins onto the SP substrates

reduced or oxidized glutathione