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In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

Therefore, inhibition of mTORC1 by rapamycin might represent a therapeutic strategy for ASD patients

These data were processed to generate outputs such as Digital Surface Models (DSM), Digital Terrain Models (DTM), orthomosaics, and point cloud datasets, all of which offer precise spatial and structural information

Finch, S., McDonnell, M