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Recent studies have revealed that in the mouse model of renal hydronephrosis induced by UUO, the expression of the ferroptosis biomarker GPX4 significantly decreases, accompanied by abnormal activation of Smad3, thereby promoting fibrosis

Here are some strategies that can help: Follow a low-histamine diet: Limiting or avoiding histamine-rich foods like aged cheeses, fermented products, cured meats, and alcohol can help manage histamine intolerance

doi: 10.1038/s41380-025-02911-7 51 Melo Dos SantosLSTrombetta-LimaMEggenBDemariaM

"Pharmacokinetics of methylene blue after oral administration." European Journal of Clinical Pharmacology, 65(2), had healthy volunteers receive oral doses of 50500 mg (higher than typical supplement range) to study absorption and elimination