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FIGURE 5 3.7 Anti-menopausal symptoms Menopause is characterized by the perturbation of the hypothalamic-pituitary-gonadal axis, including decreased estrogen levels, dysregulation of neurotransmitter such as serotonin, dopamine, and norepinephrine and an increase in the levels of the catabolic enzyme, monoamine oxidase A (MAO-A)all of which have been implicated in depressive symptoms and vasomotor instability (Table 1, Row 23) (Figure 5B)

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Epitalon remains a research compound worldwide, not approved by the FDA or equivalent regulatory agencies for medical treatment

Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice