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Though women are more highly susceptible to developing MS, men that develop this disease exhibit greater cognitive impairment and accumulate disability more rapidly than women

Most HSD-catalyzed reactions are mechanistically reversible and can function bi-directionally, although a prominent directionality is observed in vivo as a result of co-factor affinity and cellular redox status

Colognato R, Laurenza I, Fontana I, Copped F, Siciliano G, Coecke S, Aruoma OI, Benzi L, Migliore L (2006) Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine

Loading phase (with neurological symptoms): 1mg on alternate days until there is no further improvement, then every two months