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MAO-A preferentially breaks down norepinephrine, serotonin, epinephrine (adrenaline), melatonin, dopamine, kynuramine, tyramine, and tryptamine

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This impaired gut barrier function and microbial imbalance can promote the translocation of bacteria, as well as pro-inflammatory cytokines and endotoxins (e.g., LPS), into systemic circulation [141, 142]