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Rationale: Elevated GH and IGF-1 support osteoblast proliferation, collagen synthesis, and overall tissue repair capacity

This, in turn, triggers the HIF1A (hypoxia inducible factor 1 subunit alpha)-dependent Warburg effect and AIM2 (absent in melanoma 2)-dependent inflammasome activation, contributing to Kras G12D -induced pancreatic tumorigenesis [212]

Fucoxanthin: A carotenoid found in certain seaweed, shown to influence fat metabolism (4)

Pathophysiological roles and genetic insights Apolipoproteins are essential components of plasma lipoproteins, which have complex macromolecular structures composed of an envelope of phospholipids and free cholesterol, and a core of cholesteryl ester and triglyceride (TG)