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discovered an elevation in postsynaptic metabotropic GluR type-I (mGluRI) levels in mouse Fmr1 KO hippocampal neurons

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Refinement was completed after several rounds of model correction, thereby imposing non-crystallographic restraints on residues 15:50, 54:81, 100:106, 135:220, 227:240, 279:335, 342:410, 412:428, and 434:490

For general background on how investigational peptides are evaluated for safety, the National Institutes of Healths overview of how experimental compounds move through clinical evaluation illustrates why oversight matters at every stage