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Journal of Cardiovascular Development and Disease, 11 (12), 377

NCI Human Tumor Atlas Network (HTAN) Spring F2F Meeting

When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)