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These oxidative stress protections included the reduction of oxidative damage markers and enhanced antioxidant enzyme activities [71]

The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)

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M2 microglia promotes the release of anti-inflammatory factors, such as TGF- and IL-10, while M1 microglia plays an opposite role (116)