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Functional Recovery: In rat models, it preserved retinal structure and increased electroretinogram (ERG) amplitude by ~75%

Useful angiogenesis endpoints include: VEGF expression VEGFR2 pathway markers CD34 staining factor VIII staining endothelial cell response new vessel organisation blood flow related tissue markers A 2009 study looked at BPC-157 in relation to VEGF expression and angiogenic behaviour across cell culture and tissue injury models

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While the Walsh Protocol typically avoids folate in undermethylators due to its potential to increase SERT/DERT activity and reduce serotonin levels, cases of cerebral folate deficiency (CFD) require an exception