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and L.C.J

Although these changes are generally not clinically significant in healthy individuals, they could pose a greater risk in populations predisposed to metabolic disorders, such as prediabetes or type 2 diabetes

doi: 10.1016/j.jdiacomp.2022.108264 173 SelyeH

When the -helices of PrPc refold into -sheets, this gives the pathogenic PrPsc misfolded variants, and then the prion proteins become pathogenic, resulting in neurodegeneration ( 7 Akkermansia , butyrate, GLP-1, diabetes and obesity In this section, we will describe the role that the gut microbes, particularly Akkermansia muciniphila , play in protecting the host from diabetes and obesity, via the release of a protein that induces the secretion of glucagon-like peptide 1 (GLP-1) from intestinal L-cells (Rodrigues et al., 2022)