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The activation of these receptors lead to the activation of caspase-8 which can further activate caspase-3, leading to apoptosis [43]

Intranasal administration is preferred for Semax and Selank, delivering these peptides efficiently to the central nervous system where they influence BDNF production and neuroinflammation

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Spectra were acquired using a stimulated echo acquisition mode (STEAM, [39]) pulse sequence (TE/TM = 11/32 ms, TR = 5 s, number of transients = 64) with variable power radiofrequency pulses with optimised relaxation delays (VAPOR, [40]) water suppression and outer volume saturation [41]