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Whilst there is no absolute contraindication, combining berberine with metformin requires careful medical supervision due to overlapping mechanisms of action and potential additive effects on blood glucose

Thus, while this study can offer conclusions about L-GSH and spike protein effects in a cell culture model, no conclusions can be made about L-GSH effects on patients infected with COVID-19

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Insulin Resistance: Chronic, high-dose use can downregulate insulin receptors, potentially leading to long-term insulin resistance and elevated fasting glucose