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[12] It is used in pediatric patients with intrinsic cobalamin metabolic diseases, vitamin B 12 -deficient patients with tobacco amblyopia due to cyanide poisoning, and patients with pernicious anemia who have optic neuropathy

The apparent discrepancy between WT and APP/PS1 animals is likely related to the involvement of constitutive oxidative stress associated to amyloid generation in the brain of transgenic animals (Aso et al., Gpx4 isoforms expression, especially the cytoplasmic isoform