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Ipamorelin's selectivity, established by Raun and colleagues (Eur J Endocrinol, 1998), makes the CJC-1295 + ipamorelin combination uniquely suited to mechanistic research that requires clean GHS-R selectivity

In contrast, for the D3 dopamine receptor, PKC phosphorylation of the receptor leads to GRK- and arrestin-independent desensitization and internalization, in a process requiring the interaction of the D3 receptor with the actin-binding protein filamin A (Cho et al ., 2007)

Their involvement in cancer cell growth and differentiation, and in the development of resistance to anticancer agents, has made them attractive drug targets