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In their research, the flavonolignans in milk thistle proved to be quite capable of absorbing ultraviolet rays, which is one of the two basic mechanisms for protecting the skin against solar radiation.27 Melasmas Melasmas are dark patches on the skin that may result from genetic factors, exposure to ultraviolet radiation, pregnancy, the use of cosmetics, and certain drugs or therapies (e.g., hormone therapy, anti-seizure medications)

Nov-Dec 2014;48 Suppl 1:S91-95

Since the IontoPatch system includes a battery-powered device that actively delivers NAD+ into the bloodstream, its classified as a medical device

The confusion your body feels, jet lag, affects every tissue including skin