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SCFAs can function as signaling molecules with G-protein-associated receptors such as free fatty acid receptor 3 and free fatty acid receptor 2 to discharge GLP-1 and GLP-2 that regulates the tight junctions [232]

doi:10.3390/biomedicines9111547 Vasireddi N, Hahamyan H, Salata MJ, et al

This change in available IGF-1 may be (it is difficult to extrapolate data from altered IGF-1/GH concentrations from animal models, as each author measures IGF-1 levels using different methods) adequate for fatty acid (FA) oxidation in muscle, suppression of GH, stimulation of glucose transport into muscle [171, 172], and lastly for the suppression of renal gluconeogenesis in mice [163]

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