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Additionally, activation of the aryl hydrocarbon receptor (AHR) signaling pathway has been implicated in the transcriptional and possibly epigenetic regulation of both CYP27B1 and CYP24A1 ( 3.2 Dysregulation of vitamin D metabolism in chronic kidney disease In the context of CKD, the regulatory network governing vitamin D metabolism becomes markedly disrupted

When administered according to clinical guidelines, epithalon presents relatively few and minor potential side effects that cease after discontinuation of treatment

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