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Why the ADHD-Dihexa Connection Is Mechanistically Shaky Heres the part that gets glossed over in enthusiast coverage: ADHD and Alzheimers disease are not biologically similar conditions, even though both involve the brain not working the way people want it to. ADHD is fundamentally a disorder of neurotransmitter signaling, particularly underactive dopamine and norepinephrine transmission in prefrontal circuits that govern attention, working memory, and impulse control

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However, the conclusions that can be drawn from the included studies are significantly limited given small sample size, limited follow-up time, and a lack of control groups