3 Ethanol metabolism and oxidative stress in ALD 3.1 Ethanol metabolism in ALD In a healthy liver, ethanol is primarily metabolized through three main pathways: (1) The Alcohol Dehydrogenase (ADH) System: ADH, an oxidized nicotinamide adenine dinucleotide (NAD+)-dependent enzyme ( (2) The Microsomal Ethanol Oxidizing System (MEOS): This pathway involves the metabolism of ethanol to acetaldehyde in the mitochondria, converting NADPH and O 2 into oxidized nicotinamide adenine dinucleotide phosphate (NADP+) and H 2 O, while simultaneously producing ROS ( 2 O 2 ) and hydroxyl radicals (OH) ( (3) Other Oxidative Pathways: These include reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-catalase (CAT) and xanthine oxidase-catalase (XO-CAT) systems (Zima et al., 2001)
I reserve it for when it's needed, so that I'm not constantly depleting their glutathione (which is used to rid toxins from the body)
The first author is also thankful to AICTE, New Delhi for providing QIP fellowship
The control group was a heterogeneous patient population with a variety of infertility disease processes including uterine factor, anovulatory infertility, and tubal factor, each of which could have their own pathogenic process, some perhaps including aneuploidy
