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Cycling different peptides can also help maintain sensitivity while addressing multiple goals

However, the clinical benefit of this modality has still been limited due to several defects such as adverse events, acquired drug resistance, tumor recurrence, and lack of validated biomarkers, which impel further research on mechanisms of tumor angiogenesis, the development of multiple drugs and the combination therapy to figure out how to improve the therapeutic efficacy

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EDTA is also widely reported to serve as a corneal penetration enhancer resulting from improved transcellular permeability, potentially through chelating Ca 2+ from epithelial and endothelial tight junctions [47, 48]