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Peer-reviewed literature indexed on PubMed Reviews GHK-Cu modulation of gene expression related to tissue remodeling and anti-inflammatory pathways

44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops

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Origins as a Mitochondrial-Derived Peptide MOTS-C peptide was first characterized in 2015 by Lee and colleagues, who showed that stressed muscle cells release this peptide, which then translocates to the nucleus to upregulate genes involved in adaptive stress resistance