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Following a 24 h incubation period with CuCl 2 concentrations ranging from 0.2 to 0.6mmol/l, a significant copper-dependent regulation was detected for four cytokines in the cell culture supernatant of the treated cells

Initial pathway-level interrogation of the metabolomics dataset using the MetaboAnalyst 6.0 platform and the MetPa enrichment tool revealed prominent alterations in bioenergetic circuits, including the TCA cycle, glycolysis/gluconeogenesis, pyruvate metabolism, and fatty acid elongation (Fig

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