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Clinical studies published in peer-reviewed journals have documented that high-dose IV vitamin C can reduce cold and flu symptoms by up to 85% when administered early in illness

The presence of a catechol group in the B-ring, due to its ability to donate hydrogen, increases the formation of a relatively stable flavonoid-derived radical, which is the most important determinant of reactive oxygen and nitrogen species (RONS) inhibition (188)

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The pathophysiology of IC/BPS is poorly understood, and theories include chronic inflammation, autoimmune dysregulation, bacterial cystitis, urothelial dysfunction, deficiency of the glycosaminoglycan (GAG) barrier and urine cytotoxicity