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David Joffe, BSPharm, CDE Tina Burge, PharmD Candidate Florida A&M University Kiet Ngo, Pharm D Candidate Mercer University Abnormalities in incretin hormones such as the glucagon-like peptide-1 (GLP-1) contribute to the development of hyperglycemia

Subcutaneous administration (abdomen, thigh, deltoid) produces identical tissue concentrations at distant injury sites because the peptide travels through bloodstream and accumulates in areas undergoing active repair via concentration-gradient mechanisms

In some cases, a higher dose may also be necessary

Weight regain after stopping weight loss medications is well documented across the entire class of compounds, and cagrilintide is no exception