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Enhancement of the intracellular reducing equivalents such as glutathione, to increase the cellular competence to electrophiles holds promise to impede the progression of the disorder and had been clinically effective in PD patients

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MEGX is most commonly measured using immunoassay

Disrupted iron homeostasis in the brain has been increasingly implicated in the pathology of many CNS diseases, where excessive iron accumulation can lead to oxidative stress, neuroinflammation, and ferroptotic cell death in vulnerable brain regions (Salvador et al., 2010)